TCP port 110 is used by POP3, a legacy protocol for retrieving email from a mailbox.
A port is a transport layer number used together with an IP address and a protocol such as TCP or UDP to direct traffic to the correct service on a host.
A server process binds a socket to a port and listens, while a client typically chooses an ephemeral source port for outbound connections.
The combination of source and destination IP addresses, source and destination ports, and the transport protocol uniquely identifies a flow so the operating system can keep many conversations separate.
Firewalls, NAT, and scanners talk about ports because the destination port is the stable rendezvous point that exposes a service to the network.
A POP3 server listens on 110, and a mail client connects from an ephemeral source port, completes the TCP handshake, and then authenticates and issues commands to list and retrieve messages.
The typical POP model is download and optionally delete, meaning the client often pulls mail onto one device rather than keeping state synchronized across devices as IMAP does.
Without encryption, POP3 sends credentials and message contents in cleartext, which is why secure variants use TLS via STARTTLS or the implicit TLS port 995.
From a security angle, exposed POP3 services are frequent targets for password spraying and credential stuffing, since a successful login can directly expose mailbox content.